OBJECTIVES
Proton therapy is an innovative radiation technology aiming to reduce radiation-related side effects without compromising tumour control. As proton therapy is a resource-demanding treatment modality, it is crucial to identify patients who are most likely to benefit from proton therapy. In the Netherlands, patient selection is based on the probability of avoiding radiation-related side effects through applying the Normal Tissue Complication Models (NTCP). It is of great scientific and public health interests to investigate whether these models can be generalized to other countries and whether the ‘model-based’ approach of patient selection would benefit the society through health economic analysis. To assess the external validity of NTCP models, it is crucial to obtain data from other European countries.
This call aims to invite ENCR-members to join forces in this project.
DATA
What data are needed for the project:
• Patients with cancer at the following tumour sites: Oral cavity (C01-C06), Oropharynx (C09-C10), Nasopharynx (C11), Hypopharynx (C12-C13), Larynx (C32);
• Period of radiotherapy treatment 2018-2020;
• See list of variables to be collected
• Per country ~100 outcome events (not patients) are required. With an average prevalence of events of ±30%, it needs around 300-400 patients per country;
DATA COLLECTION
• Data collection will be financially supported by the HTx project; a total amount of €100,000 is available, resulting in an amount per patient of €25-€50, depending of the number of participating registries
• EORTC will provide a code book, with the required format for each variable
NEXT STEPS
• Introductory webinar regarding the project (Nov 10 2022)
• Express of interests of participation (Nov 2022)
• Feasibility discussion with interested registries (Nov 2022)
• Administrative supports (e.g. data collection contract) (Dec 2022)
• Data collection (Jan-May 2023)
• Data delivery (June 2023)
INFORMATION WEBINAR
An information webinar took place on Thursday, Nov 10